Endocrine Abstracts

Coxsackievirus and adenovirus receptor (CXADR) is localized at the blood-testis barrier (BTB) and at the interface between Sertoli cells (SC) and germ cells (GC). Earlier studies indicated that CXADR plays role in BTB function and germ cell migration. However, conventional knockout of CXADR leads to embryonic lethality, making the study of CXADR in the testis impossible. We aim to generate SC-specific CXADR knockout (KO) mice to evaluate the SC-specific function of CXADR on sp...